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KMID : 0383820070620050382
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Tuberculosis and Respiratory Diseases
2007 Volume.62 No. 5 p.382 ~ p.388
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Cognitive Dysfunction in non-hypoxemic COPD Patients
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Kim Woo-Jin
Han Sun-Sook
Park Myoung-Ok
Lee Seung-Jun
Kim Seong-Jae
Lee Jung-Hie
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Abstract
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Background: The cognitive function is impaired in patients with hypoxemic chronic obstructive pulmonary disease (COPD). However, there are conflicting results regarding the cognitive function in patients with non-hypoxemic COPD. COPD patients also have sleep disorders. This study examined the cognitive function in non-hypoxemic COPD patients, and nocturnal sleep was assessed in COPD patients with a cognitive dysfunction.
Methods: Twenty-eight COPD patients (mean age, 70.7 years) with an oxygen saturation > 90%, and 33 healthy control subjects (mean age, 69.5 years) who had visited for a routine check-up were selected. The neurocognitive tests were performed using the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD-K) Neuropsychological Battery.
Results: The scores of the word list recall test (p=0.03) and the word list recognition test (p=0.006) in the COPD group were significantly lower than those in the control group. Nine patients showed a significantly impaired cognitive function. Seven of these underwent polysomnography, which revealed apnea-hypopnea indices > or = five per hour in five patients. The median oxygen desaturation index and median limb movement index were 3.6/h and 38.6/h, respectively.
Conclusion: These results suggest that the verbal memory function is impaired in non-hypoxemic COPD patients. Six out of seven COPD patients with an impaired cognitive function had sleep disorders of sleep apnea and/or periodic limb movements during sleep.
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KEYWORD
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Chronic obstructive pulmonary disease, Cognitive function, Sleep disorders
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